Supplemented shenqi dihuang decoction formula

1. Supplemented shenqi dihuang decoction formula decreases mitochondrial ultrastructural damage in rat cells.

   “SSDDF-H containing serum multi-targetedly improved HG-induced senescence, fibrotic injury, SASP expression, ferroptosis marker levels and mitochondrial ultrastructural damage in renal tubular epithelial cells”

   CellsHigh glucose-treated NRK-52E cellsSSDDF-H containing serumrenal tubular epithelial cellsHigh dose; quantity not stated

   Effects and mechanisms of Supplemented Shenqi Dihuang Decoction Formula improving renal aging and tubulointerstitial fibrosis in diabetic kidney disease by inhibiting ferroptosis

   Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·1 Sep 2026

1. Supplemented shenqi dihuang decoction formula decreases fibrotic injury in rat cells.

   “SSDDF-H containing serum multi-targetedly improved HG-induced senescence, fibrotic injury”

   CellsHigh glucose-treated NRK-52E cellsSSDDF-H containing serumrenal tubular epithelial cellsHigh dose; quantity not stated

   Effects and mechanisms of Supplemented Shenqi Dihuang Decoction Formula improving renal aging and tubulointerstitial fibrosis in diabetic kidney disease by inhibiting ferroptosis

   Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·1 Sep 2026

1. Supplemented shenqi dihuang decoction formula decreases cellular senescence in rat cells.

   “SSDDF-H containing serum multi-targetedly improved HG-induced senescence”

   CellsHigh glucose-treated NRK-52E cellsSSDDF-H containing serumrenal tubular epithelial cellsHigh dose; quantity not stated

   Effects and mechanisms of Supplemented Shenqi Dihuang Decoction Formula improving renal aging and tubulointerstitial fibrosis in diabetic kidney disease by inhibiting ferroptosis

   Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·1 Sep 2026

More on Cellular senescence

1. Supplemented shenqi dihuang decoction formula inhibits ferroptosis in rats.

   “SSDDF also ameliorated renal lipid peroxidation-dependent ferroptosis in DKD rats”

   AnimalsType 2 diabetic kidney disease modelkidneySix weeks

   Effects and mechanisms of Supplemented Shenqi Dihuang Decoction Formula improving renal aging and tubulointerstitial fibrosis in diabetic kidney disease by inhibiting ferroptosis

   Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·1 Sep 2026

More on Ferroptosis

1. Supplemented shenqi dihuang decoction formula decreases tubulointerstitial fibrosis in rats.

   “SSDDF ameliorated the aging phenotypes, BW, BG, UNAG levels, as well as RA and TIF in DKD model rats”

   AnimalsType 2 diabetic kidney disease modelkidneyLow and high doses; quantities not statedSix weeks

   Effects and mechanisms of Supplemented Shenqi Dihuang Decoction Formula improving renal aging and tubulointerstitial fibrosis in diabetic kidney disease by inhibiting ferroptosis

   Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·1 Sep 2026

More on Tubulointerstitial fibrosis

1. Supplemented shenqi dihuang decoction formula decreases renal aging in rats.

   “SSDDF ameliorated the aging phenotypes, BW, BG, UNAG levels, as well as RA and TIF in DKD model rats”

   AnimalsType 2 diabetic kidney disease modelkidneyLow and high doses; quantities not statedSix weeks

   Effects and mechanisms of Supplemented Shenqi Dihuang Decoction Formula improving renal aging and tubulointerstitial fibrosis in diabetic kidney disease by inhibiting ferroptosis

   Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·1 Sep 2026