STM2457

1. STM2457 increases cytoplasmic dsRNA in human cells.

   “Rather than causing broad transposable-element derepression, m6A inhibition promoted cytoplasmic double-stranded RNA accumulation and a selective HERVK-associated response.”

   CellsHMC3

   Loss of m6A unmasks a senescence-associated inflammatory program in human microglia

   bioRxiv·8 Jul 2026Preprint

More on Cytoplasmic dsRNA

1. STM2457 activates senescence-associated secretory phenotype (SASP) in human cells.

   “Transcriptomic profiling revealed suppression of mitotic gene programs together with a SASP-like inflammatory output marked by NF-{kappa}B and interferon signatures.”

   CellsHMC3

   Loss of m6A unmasks a senescence-associated inflammatory program in human microglia

   bioRxiv·8 Jul 2026Preprint

More on Senescence-associated secretory phenotype (SASP)

1. STM2457 increases senescence-associated beta-galactosidase in human cells.

   “This state includes increased senescence-associated {beta}-galactosidase activity, elongated cellular morphology, reduced proliferation, Lamin B1 loss, and remodeling of nuclear architecture.”

   CellsHMC3

   Loss of m6A unmasks a senescence-associated inflammatory program in human microglia

   bioRxiv·8 Jul 2026Preprint

More on Senescence-associated beta-galactosidase

1. STM2457 induces cellular senescence in human cells.

   “STM2457 lowers global m6A and is sufficient to induce a senescence-like inflammatory state in human HMC3 microglia.”

   CellsHMC3

   Loss of m6A unmasks a senescence-associated inflammatory program in human microglia

   bioRxiv·8 Jul 2026Preprint

More on Cellular senescence

1. STM2457 decreases N6-methyladenosine in human cells.

   “selective catalytic inhibition of METTL3 with STM2457 lowers global m6A”

   CellsHMC3

   Loss of m6A unmasks a senescence-associated inflammatory program in human microglia

   bioRxiv·8 Jul 2026Preprint

More on N6-methyladenosine