Cytoplasmic dsRNA

1. STM2457 increases cytoplasmic dsRNA in human cells.

   “Rather than causing broad transposable-element derepression, m6A inhibition promoted cytoplasmic double-stranded RNA accumulation and a selective HERVK-associated response.”

   CellsHMC3

   Loss of m6A unmasks a senescence-associated inflammatory program in human microglia

   bioRxiv·8 Jul 2026Preprint

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