Social activity

11 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 2 countries

Human trial1
Humans8
In silico1

Outcomes

Amygdala volume

upin humans1

1 study

Social activity increases amygdala volume in humans (β=0.13±0.05, p=0.007).
“Amygdala volume was positively associated with healthy changes in SA (β=0.13±0.05;p=0.007)”
Humansamygdalan = 378
Life‐Course Behavioral Changes: Impact on Cognitive Performance, Resilience, and Disease Biomarkers in Late‐Life
AAIC 2025 abstract23 Dec 2025

Associations

Delayed recall memory

downin humans1

1 study

Social activity is associated with delayed recall memory in humans (r = -.37, p = .01).
“Greater total dNA social domain activity was correlated with poorer RAVLT delayed recall ( r = ‐.37, p = .01).”
Humansfamily history of Alzheimer's diseasefemalesn = 47
Lifetime activity scores in women at risk for Alzheimer's disease and relationship with midlife memory and executive function
AAIC 2025 abstract23 Dec 2025

Dementia

downin humans1HR 2.36

1 study

Social activity lowers the risk of dementia in humans (HR 2.36, 95% CI 1.29-4.32).
“Individuals who did not participate in any social activities had a significantly higher risk of developing dementia than those who were socially active (hazard ratio: 2.36; 95% confidence interval = 1.29-4.32).”
Humansretrospective cohort studyn = 6,156
Effect of Social Activity on All-Cause Dementia Among South Korean Elders: A Retrospective Cohort Study
Health science reports18 Jun 2025