Late-life depression
Disease3 papers1 finding
- Humans3
Associations
1Functional limitations
no changein humans1
1 study
Functional limitations
no changein humans1
Late-life depression is associated with functional limitations in humans.
Humanslate-life depression6 yearsn = 355
Six-year trajectories of cognitive, physical and social functioning in adults with late-life depression · Journal of affective disorders · 9 Sep 2026
Trial sponsors
Washington University School of Medicine
1 trialPhase 4742 people
Centre for Addiction and Mental Health
1 trialPhase 487 people
Funding
National Institute of Mental HealthUS$4m3 grants since 2013
Characterizing Cognitive Decline in Late Life Depression: The ADNI-D Project
National Institute of Mental HealthUniversity of California, San FranciscoUS$806.6k2013–2027
National Institute of Mental HealthUniversity of California, San FranciscoUS$3.1m2025–2030
National Institute of Mental HealthUniversity of Pittsburgh at PittsburghUS$79.5k2024–2026
Latest
12Exercise benefits on late-life depression differ across nations
A preprint finds physical activity protected against depressive symptoms in US older adults (β = −2.734), but effects varied by education and living…A preprint finds physical activity protected against depressive symptoms in US older adults (β = −2.734), but effects varied by education and living arrangements across countries.
Persistent depression links to faster frailty accumulation
Persistent high depressive symptoms predicted faster non-cognitive frailty accumulation at 1.42 × 10-3/year and elevated odds of incident frailty…Persistent high depressive symptoms predicted faster non-cognitive frailty accumulation at 1.42 × 10-3/year and elevated odds of incident frailty across three aging cohorts.