SLU-PP-332

1. SLU-PP-332 improves stem cell differentiation in human cells.

   “Furthermore, SLU-PP-332 treatment promoted abundant myotube formation, positively influencing cell differentiation.”

   Cellsin myoblasts isolated from muscle of inactive women15 days

   Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study

   Frontiers in physiology·Jul 7, 2025

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1. SLU-PP-332 decreases oxidative stress and ROS signaling in human cells.

   “SLU-PP-332 treatment promoted down-regulation of NOX4 and upregulation of SIRT1, PGC-1α, ERRα, FNDC5, Akt, and B-cell lymphoma 2 (Bcl-2) in myoblasts, reducing cytotoxicity, oxidative stress, and senescence”

   Cellsin myoblasts isolated from muscle of inactive women

   Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study

   Frontiers in physiology·Jul 7, 2025

More on Oxidative stress and ROS signaling

1. SLU-PP-332 decreases cellular senescence in human cells.

   “SLU-PP-332 treatment promoted down-regulation of NOX4 and upregulation of SIRT1, PGC-1α, ERRα, FNDC5, Akt, and B-cell lymphoma 2 (Bcl-2) in myoblasts, reducing cytotoxicity, oxidative stress, and senescence”

   Cellsin myoblasts isolated from muscle of inactive women

   Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study

   Frontiers in physiology·Jul 7, 2025

More on Cellular senescence

1. SLU-PP-332 inhibits inflammation in mice.

   “similar to CR, an 8-week treatment with a pan-ERR agonist reversed the age-related increases in albuminuria, podocyte loss, mitochondrial dysfunction, and inflammatory cytokines”

   Animalskidney8 weeks

   Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

   The American journal of pathology·Sep 17, 2023

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1. SLU-PP-332 decreases podocyte loss in mice.

   “similar to CR, an 8-week treatment with a pan-ERR agonist reversed the age-related increases in albuminuria, podocyte loss, mitochondrial dysfunction, and inflammatory cytokines”

   Animalskidney8 weeks

   Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

   The American journal of pathology·Sep 17, 2023

1. SLU-PP-332 decreases albuminuria in mice.

   “similar to CR, an 8-week treatment with a pan-ERR agonist reversed the age-related increases in albuminuria, podocyte loss, mitochondrial dysfunction, and inflammatory cytokines”

   Animalskidney8 weeks

   Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

   The American journal of pathology·Sep 17, 2023

More on Albuminuria