Saikosaponin d

1. Saikosaponin d mediates EPHB2 in human cells.

   “Crucially, overexpressing EPHB2 abolished all the protective effects of SSD.”

   Cellsfor protective effects of SSD in OX-LDL-treated hVSMCs

   Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2

   Clinical and experimental pharmacology & physiology·1 Jun 2026

2. Saikosaponin d inhibits EPHB2 in human cells.

   “Molecular studies confirmed that SSD directly binds to EPHB2 and downregulates its expression.”

   Cells

   Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2

   Clinical and experimental pharmacology & physiology·1 Jun 2026

More on EPHB2

1. Saikosaponin d improves autophagy in human cells.

   “SSD significantly attenuated OX-LDL-induced oxidative stress, inflammation, lipid accumulation, autophagic flux impairment and cellular senescence in hVSMCs.”

   Cellsin OX-LDL-treated hVSMCs

   Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2

   Clinical and experimental pharmacology & physiology·1 Jun 2026

More on Autophagy

1. Saikosaponin d decreases cellular senescence in human cells.

   “SSD significantly attenuated OX-LDL-induced oxidative stress, inflammation, lipid accumulation, autophagic flux impairment and cellular senescence in hVSMCs.”

   Cellsin OX-LDL-treated hVSMCs

   Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2

   Clinical and experimental pharmacology & physiology·1 Jun 2026

More on Cellular senescence