Pyrroloquinoline quinone

Intervention3 papers9 findingsPubChem 1024ChEBI 18315

One animal and cell study shows pyrroloquinoline quinone improves cognition and hippocampal neuronal integrity in animals and reduces reactive oxygen species in HT-22 hippocampal neuronal cells. Preprint reviews describe cognitive benefits, prevention of cellular senescence and reduced oxidative stress.

Animals1

Outcomes

7

Cognitive function

upin reviews2upin animals1Very low certainty

3 studies

Pyrroloquinoline quinone improves cognitive function.
Review
Cognitive Frailty in Malaysia: A Perspective for Healthy Aging Through Pyrroloquinoline Quinone as a Nutritional Strategy · Preprints.org · 7 Sep 2026 · Preprint
Pyrroloquinoline quinone improves cognitive function.
Review
Cognitive Frailty in Malaysia: A Perspective for Healthy Aging Through Pyrroloquinoline Quinone as a Nutritional Strategy · Preprints.org · 3 Sep 2026 · Preprint
Pyrroloquinoline quinone improves cognitive function.
Animals
Pyrroloquinoline Quinone Improves Cognitive-Related Behavioral Performance Associated with Enhanced Mitochondrial Bioenergetics in Naturally Aged Mice · Antioxidants (Basel, Switzerland) · 24 Jul 2026

Cellular senescence

downin reviews1

1 study

Pyrroloquinoline quinone prevents cellular senescence.
Review
Cognitive Frailty in Malaysia: A Perspective for Healthy Aging Through Pyrroloquinoline Quinone as a Nutritional Strategy · Preprints.org · 7 Sep 2026 · Preprint

Cellular senescence →

Oxidative stress and ROS signalling

downin reviews1

1 study

Pyrroloquinoline quinone decreases oxidative stress and ROS signalling.
Review
Cognitive Frailty in Malaysia: A Perspective for Healthy Aging Through Pyrroloquinoline Quinone as a Nutritional Strategy · Preprints.org · 7 Sep 2026 · Preprint

Oxidative stress and ROS signalling →

UCP2

downin animals1Very low certainty

1 study

Pyrroloquinoline quinone decreases UCP2.
Animalshippocampus
Pyrroloquinoline Quinone Improves Cognitive-Related Behavioral Performance Associated with Enhanced Mitochondrial Bioenergetics in Naturally Aged Mice · Antioxidants (Basel, Switzerland) · 24 Jul 2026

SIRT1

upin animals1Very low certainty

1 study

Pyrroloquinoline quinone increases SIRT1.
Animalshippocampus
Pyrroloquinoline Quinone Improves Cognitive-Related Behavioral Performance Associated with Enhanced Mitochondrial Bioenergetics in Naturally Aged Mice · Antioxidants (Basel, Switzerland) · 24 Jul 2026

Reactive oxygen species

downin cells1Very low certainty

1 study

Pyrroloquinoline quinone decreases reactive oxygen species in cells.
CellsHT-22 hippocampal neuronal cells
Pyrroloquinoline Quinone Improves Cognitive-Related Behavioral Performance Associated with Enhanced Mitochondrial Bioenergetics in Naturally Aged Mice · Antioxidants (Basel, Switzerland) · 24 Jul 2026

Reactive oxygen species →

Hippocampal neuronal integrity

upin animals1Very low certainty

1 study

Pyrroloquinoline quinone improves hippocampal neuronal integrity.
Animalshippocampus
Pyrroloquinoline Quinone Improves Cognitive-Related Behavioral Performance Associated with Enhanced Mitochondrial Bioenergetics in Naturally Aged Mice · Antioxidants (Basel, Switzerland) · 24 Jul 2026

Latest

3

Preprints.orgReviewPreprint9 Sep

Cognitive Frailty in Malaysia: A Perspective for Healthy Aging Through Pyrroloquinoline Quinone as a Nutritional Strategy

Preprints.orgReviewPreprint8 Sep

Cognitive Frailty in Malaysia: A Perspective for Healthy Aging Through Pyrroloquinoline Quinone as a Nutritional Strategy

AntioxidantsAnimals27 Aug

Pyrroloquinoline Quinone Improves Cognitive-Related Behavioral Performance Associated with Enhanced Mitochondrial Bioenergetics in Naturally Aged Mice