Two dietary compounds prolonged survival in short-lived mice
Survival days at the 75th percentile increased by 73% with pyrroloquinoline quinone and 36% with imidazopyrroloquinoline in lifelong feeding experiments, compared with controls.
Limit: Survival gains describe the 75th percentile, not average lifespan
Edited by Boris Djordjevic · AgingResearch.News
Mice of the short-lived, senescence-accelerated P8 strain received supplemented diets in lifelong and midlife animal experiments. The diets contained either pyrroloquinoline quinone (PQQ), a vitamin-like compound, or its derivative imidazopyrroloquinoline (IPQ), each at 0.02% by weight.
In the lifelong experiments, survival days at the 75th percentile increased by 73% with PQQ and 36% with IPQ compared with controls. Both compounds delayed the appearance of aging and age-related muscle dysfunction. Starting either supplemented diet in midlife improved muscle function that had declined with age. IPQ also reduced fat accumulation in fat tissue and the liver. The authors concluded that both compounds reduced mortality risk during midlife.
Why it matters
Age-related muscle decline raises questions about preserving function alongside extending life. The experiments explored whether these dietary compounds could promote healthy longevity.
Caveats
These were animal experiments in a short-lived mouse strain, not tests in people. The reported survival gains describe the 75th percentile, not average lifespan.
Pyrroloquinoline quinone is part of Rhonda Patrick's supplement routineMore supplements