Platelet factor 4

2 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Heart, Lung, and Blood Institute and 4 more

Animals2

Outcomes

Cell polarity

upin mice1

1 study

Platelet factor 4 improves cell polarity in mice.
“recombinant PF4 administration restored old HSCs to youthful functional phenotypes characterized by improved cell polarity”
Animalsaged HSCs
Platelet factor 4 regulates hematopoietic stem cell aging
Blood4 Dec 2025

Reconstitution capacity

upin mice1

1 study

Platelet factor 4 improves reconstitution capacity in mice.
“recombinant PF4 administration restored old HSCs to youthful functional phenotypes characterized by improved cell polarity, reduced DNA damage, enhanced in vivo reconstitution capacity”
Animalsaged HSCs
Platelet factor 4 regulates hematopoietic stem cell aging
Blood4 Dec 2025

DNA damage

downin mice1

1 study

Platelet factor 4 decreases DNA damage in mice.
“recombinant PF4 administration restored old HSCs to youthful functional phenotypes characterized by improved cell polarity, reduced DNA damage”
Animalsaged HSCs
Platelet factor 4 regulates hematopoietic stem cell aging
Blood4 Dec 2025