N-acetylglucosamine

N-acetylglucosamine has been studied in 4 papers since 2003: none in people yet, 1 in animals, 2 in cells, 1 review. The research so far is in animals and cells.

4 papers study it20 more mention it1 findingUpdated Oct 12, 2022

None of its findings points the other way.

2 independent labs in 1 country

Funder: National Heart, Lung, and Blood Institute

Animals1
Cells2

What did lifespan studies of N-acetylglucosamine find?

DrugAge records 1 result from 1 paper: 1 in C. elegans. Average lifespan is the mean or the median, as each paper reports it.

C. elegansN2, 10 mM+50% average

What did studies of N-acetylglucosamine find?

1

Studies of N-acetylglucosamine measured 1 outcome; the most studied are CD4+ T-cell proliferation (1 study).

CD4+ T-cell proliferation

no changein cells1

1 study

N-acetylglucosamine has no effect on CD4+ T-cell proliferation in cells.
“GlcN, but not GlcNAc, inhibits CD4+ T-cell proliferation”
Cellsin primary and secondary mixed lymphocyte cultures
Immunobiological effects of glucosamine in vitro
Scandinavian journal of immunologyOct 1, 2003

More on CD4+ T-cell proliferation

Funding

1 grant since 2020

National Heart, Lung, and Blood InstituteUS$222.8k

The role of protein O-linked N-Acetylglucosamine in regulating cardiac physiology
National Heart, Lung, and Blood InstituteUniversity of Alabama at BirminghamUS$222.8k2020–2022

Latest

4 papers in 12 months

Protein & CellJul 27

CRISPR screening identifies GNPTAB as a noncanonical STING activator driving cellular senescence

Experiments in human cellsCellular senescence

The Journal of Biological ChemistryJul 17

O-GlcNAcylation is a mitochondrial-nuclear signal that regulates passive transport through the nuclear pore complex

Experiments in human cellsMitochondrion

bioRxivFeb 14

Mapping the endothelial O-GlcNAcome uncovers CCAR1 as a regulator of senescence

Preprint: experiments in human cellsCell cycle regulation

Rejuvenation ResearchNov 22

Immunoglobulin G and Aging: Biological Functions and Its Crosstalk with the Gut Microbiota

ReviewMicrobiome composition

The EPMA JournalSep 15

Establishment of reference intervals for serum immunoglobulin G N-glycosylation features in healthy Chinese adults: a nationwide survey in the framework of predictive, preventive, and personalized medicine

Cross-sectional study of 927 peopleBiomarkers

G3Aug 19

Integrated ecdysone and O-linked N-acetylglucosamine signaling coordinates intestinal stem cell proliferation in Drosophila midgut

Experiments in fliesGut and microbiome

Stem Cell Research & TherapyJan 24

MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB

Experiments in human cellsCellular senescence

ReproductionOct 15

O-GlcNAc participates in the meiosis of aging oocytes by mediating mitochondrial function

Experiments in mouse cellsMitochondrion

GeroScienceJun 15

Glycan clock of ageing-analytical precision and time-dependent inter- and i-individual variability

Cohort study of 312 peopleBiomarkers

Cell Death DiscoveryMay 16

Age-related elevation of O-GlcNAc causes meiotic arrest in male mice

Experiments in miceMechanisms