Matrix stiffness

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Institutes of Health

Cells1

Outcomes

Transzonal projections

downin mouse cells1

1 study

Matrix stiffness decreases transzonal projections in mouse cells.
“In stiff conditions, the number of transzonal projections decreased.”
Cellsovary
Increased stiffness mimicking ovarian aging induces a fibroinflammatory response in follicles and impairs oocyte quality
Reproduction (Cambridge, England)23 Jan 2026

Inflammation

upin mouse cells1

1 study

Matrix stiffness induces inflammation in mouse cells.
“follicles respond rapidly to increased stiffness and exhibit enrichment in genes related to inflammation and extracellular matrix remodeling.”
Cellsovary
Increased stiffness mimicking ovarian aging induces a fibroinflammatory response in follicles and impairs oocyte quality
Reproduction (Cambridge, England)23 Jan 2026