Lanatoside C

Lanatoside C has been studied in 3 papers since 2025: none in people yet, 1 in animals, 1 in cells, 1 review; 2 in the past year. The research so far is in animals and cells. The newest story, Nov 10, 2026: “Drug may target lab-grown human cells with reduced TET2 gene function”.

Intervention

3 papers study it5 findingsUpdated Nov 9, 2026

PubChem

1 new paper in 30 daysSee all 3 papers on lanatoside C

At a glance

The findings reach mice, none yet in people. 2 independent labs in 1 country.

None of its findings points the other way.

2 independent labs in 1 country

Funders: Ministry of Science and ICT, South Korea and others

Animals1
Cells1

What did studies of lanatoside C find?

Studies of lanatoside C measured 5 outcomes, among them relative donor-derived monocyte and neutrophil frequencies, macrophage apoptosis and apoptosis.

Relative donor-derived monocyte and neutrophil frequencies

downin mice1

1 study

Lanatoside C decreases relative donor-derived monocyte and neutrophil frequencies in mice (partial donor-cell reconstitution model with Tet2-deficient donor-cell recipients).
“Lanatoside C reduced relative donor‐derived monocyte and neutrophil frequencies in Tet2‐deficient donor‐cell recipients”
Animalspartial donor-cell reconstitution model with Tet2-deficient donor-cell recipients
Drug may target lab-grown human cells with reduced TET2 gene function
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Nov 9, 2026

More on Relative donor-derived monocyte and neutrophil frequencies

macrophage apoptosis

upin cells1

1 study

Lanatoside C induces macrophage apoptosis in cells (TET2-deficient macrophages compared with control cells).
“The cardiac glycoside Lanatoside C preferentially induces mitochondrial depolarization and apoptosis in TET2 ‐deficient macrophages, with substantially smaller effects in control cells.”
CellsTET2-deficient macrophages compared with control cellsmacrophage
Drug may target lab-grown human cells with reduced TET2 gene function
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Nov 9, 2026

Apoptosis

upin human cells1

1 study

Lanatoside C increases apoptosis in senescent HUVECs.
“We found that Lana C depolarized and acidified senescent human umbilical vein endothelial cells (HUVECs), making them susceptible to apoptosis.”
Cellsin senescent HUVECs
Lanatoside C, a Novel Senolytic, Ameliorates Atherosclerosis in Mice
Aging and diseaseApr 21, 2025

Latest

2 papers in 12 months

Advanced ScienceNov 10

Drug may target lab-grown human cells with reduced TET2 gene function

A 48-hour screen of 489 compounds identified lanatoside C as a candidate for preferentially killing human immune cells with reduced TET2 gene function.A 48-hour screen of 489 compounds identified lanatoside C as a candidate for preferentially killing human immune cells with reduced TET2 gene function.

Human cell studyInterventions