AgingResearch.NewsJoin free

L-carnosine

Intervention

1 paper2 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: American Heart Association and 3 more
  • Animals1

Outcomes

2

Senescence biomarker expression

downin mice1

1 study

  1. L-carnosine decreases senescence biomarker expression in mice.

    “L-carnosine reduced the abundance of 4-HNE-modified proteins and blunted the expression of senescence biomarkers CDKN1A (p21Cip1), PLAUR, BCL2L1, and BCL2L2.”

    Animalsobese C57BL/6J mice; CDKN1A, PLAUR, BCL2L1 and BCL2L2 expressionvisceral adipose tissue

    Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells

    Aging cell11 Oct 2024

More on Senescence biomarker expression

4-HNE-modified proteins

downin mice1

1 study

  1. L-carnosine decreases 4-HNE-modified proteins in mice.

    “in visceral fat of obese C57BL/6J mice, L-carnosine reduced the abundance of 4-HNE-modified proteins”

    Animalsobese C57BL/6J micevisceral adipose tissue

    Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells

    Aging cell11 Oct 2024

More on 4-HNE-modified proteins

Latest

Related