Fusobacterium nucleatum

1. Fusobacterium nucleatum induces cellular senescence in human cells.

   “Fusobacterium nucleatum induced decreased OMF viability, increased SA-β-gal positive cells, cell senescence, and SASP-related factor levels, and caused OMF arrest in the G1 phase.”

   Cellsco-culture in vitro100 multiplicity of infection

   Fusobacterium nucleatum promotes senescence of human oral mucosa fibroblasts via the Wnt5A/mTOR pathway

   Odontology·Jan 21, 2026

2. Fusobacterium nucleatum induces cellular senescence in cells.

   “Fn induces dose- and time-dependent ROS production, disrupts redox homeostasis, and promotes endothelial senescence and dysfunction.”

   Cellsin vitro infection

   Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance

   mBio·Jan 8, 2026

3. Fusobacterium nucleatum increases cellular senescence.

   “increased oxidative stress and vascular senescence, and impaired endothelial function.”

   Animalschronic infection

   Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance

   mBio·Jan 8, 2026

More on Cellular senescence

1. Fusobacterium nucleatum increases abdominal aortic aneurysm progression in mice.

   “topical application of Fn aggravated AngII-induced AAA in mice.”

   Animalsangiotensin II-induced abdominal aortic aneurysm

   Fusobacterium nucleatum-Derived Isoleucine Exacerbates Aneurysm by Inducing Ferroptosis in Vascular Smooth Muscle Cells

   Arteriosclerosis, thrombosis, and vascular biology·May 28, 2026

1. Fusobacterium nucleatum inhibits autophagy in human cells.

   “Fusobacterium nucleatum inhibited autophagy of OMFs via the Wnt5A/mTOR pathway.”

   Cellsco-culture in vitro100 multiplicity of infection

   Fusobacterium nucleatum promotes senescence of human oral mucosa fibroblasts via the Wnt5A/mTOR pathway

   Odontology·Jan 21, 2026

More on Autophagy

1. Fusobacterium nucleatum increases atherosclerosis.

   “chronic Fn infection accelerated atherosclerotic plaque progression, increased oxidative stress and vascular senescence, and impaired endothelial function.”

   Animalschronic infection

   Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance

   mBio·Jan 8, 2026

More on Atherosclerosis

1. Fusobacterium nucleatum increases radioresistance in human cells.

   “Fn inhibited PANoptosis by the SLC7A5/leucine-mTORC1 axis during irradiation stress, thus promoting radioresistance.”

   Cellsduring irradiation stress

   Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma

   Cell reports. Medicine·Oct 1, 2024

1. Fusobacterium nucleatum inhibits apoptosis in human cells.

   “Fn inhibited PANoptosis by the SLC7A5/leucine-mTORC1 axis during irradiation stress, thus promoting radioresistance.”

   Cellsunder irradiation stress

   Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma

   Cell reports. Medicine·Oct 1, 2024

More on Apoptosis