Fusobacterium nucleatum abundance

1. Resistance training + multi-nutrient supplementation decreases Fusobacterium nucleatum abundance in rats.

   “combined resistance training and multi-nutrient supplementation (L. plantarum, B. bifidum, vitamin D, leucine) upregulates mTOR/IGF-1/S6K1 signaling and reduces Fusobacterium nucleatum in aged male rats”

   Animalsgut8-weekmalesn = 35

   mTOR-Gut Microbiome Interaction in Aging: Fusobacterium nucleatum, Resistance Training and Multi-nutrient Supplementation Effects in Aged Male Rats

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·25 Jul 2026

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1. Fusobacterium nucleatum abundance is associated with IGF-1 in rats (r = -0.81).

   “Fn correlates strongly with S6K1 (r = -0.85) and IGF-1 (r = -0.81)”

   Animals8-weekmalesn = 35

   mTOR-Gut Microbiome Interaction in Aging: Fusobacterium nucleatum, Resistance Training and Multi-nutrient Supplementation Effects in Aged Male Rats

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·25 Jul 2026

More on IGF-1

1. Fusobacterium nucleatum abundance is associated with abdominal aortic aneurysm in humans.

   “Patients with AAA showed a marked enrichment of Fn in dental plaque”

   Humanspatients with abdominal aortic aneurysm versus matched healthy controlsdental plaque

   Fusobacterium nucleatum-Derived Isoleucine Exacerbates Aneurysm by Inducing Ferroptosis in Vascular Smooth Muscle Cells

   Arteriosclerosis, thrombosis, and vascular biology·28 May 2026

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