Empagliflozin + exercise
Empagliflozin + exercise has been studied in 2 papers since 2026: none in people yet, 2 in animals; 2 in the past year. The research so far is in animals. The newest paper, Jul 7, 2026: “Effects of empagliflozin alone and in combination with exercise on the soleus muscle in obese type 2 diabetic rats”.
2 papers study it9 findingsUpdated
See all 2 papers on empagliflozin + exercise
At a glance
The findings reach mice, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Boehringer Ingelheim and 2 more
- 4 of 9 findings with company ties
- Animals2
What did studies of empagliflozin + exercise find?
9Studies of empagliflozin + exercise measured 9 outcomes, among them autophagy, citrate synthase activity and triglyceride.
Autophagy
upin rats1
1 study
Autophagy
upin rats1
Empagliflozin + exercise activates autophagy in rats (spontaneously diabetic Torii fatty rats).
“Combination treatment significantly enhanced citrate synthase activity, mitochondrial functional protein expression, and autophagic flux.”
Animalsspontaneously diabetic Torii fatty ratssoleus8 weeksmales
The journal of physiological sciences : JPS
Citrate synthase activity
upin rats1
1 study
Citrate synthase activity
upin rats1
Empagliflozin + exercise increases citrate synthase activity in rats (spontaneously diabetic Torii fatty rats).
“Combination treatment significantly enhanced citrate synthase activity, mitochondrial functional protein expression, and autophagic flux.”
Animalsspontaneously diabetic Torii fatty ratssoleus8 weeksmales
The journal of physiological sciences : JPS
Triglyceride
downin rats1
1 study
Triglyceride
downin rats1
Empagliflozin + exercise decreases triglyceride in rats (spontaneously diabetic Torii fatty rats, compared with EMPA alone).
“Additionally, the combined treatment reduced total cholesterol and triglycerides compared with EMPA alone.”
Animalsspontaneously diabetic Torii fatty rats, compared with EMPA alone8 weeksmales
The journal of physiological sciences : JPS
Total cholesterol
downin rats1
1 study
Total cholesterol
downin rats1
Empagliflozin + exercise decreases total cholesterol in rats (spontaneously diabetic Torii fatty rats, compared with EMPA alone).
“Additionally, the combined treatment reduced total cholesterol and triglycerides compared with EMPA alone.”
Animalsspontaneously diabetic Torii fatty rats, compared with EMPA alone8 weeksmales
The journal of physiological sciences : JPS
GFAP+ astrocytes
no changein rats1
1 study
GFAP+ astrocytes
no changein rats1
Empagliflozin + exercise showed no clear effect on GFAP+ astrocytes in amyloid-beta-induced Alzheimer's rat model.
“did not notably affect astrocyte activity”
Animalsin amyloid-beta-induced Alzheimer's rat modelbrain28 days
Current medicinal chemistry
necrotic cell death
downin rats1
1 study
necrotic cell death
downin rats1
Empagliflozin + exercise decreases necrotic cell death in amyloid-beta-induced Alzheimer's rat model.
“it diminished necrotic cell death and reduced Aβ plaques”
Animalsin amyloid-beta-induced Alzheimer's rat modelbrain28 days
Current medicinal chemistry
Amyloid-beta plaques
downin rats1
1 study
Amyloid-beta plaques
downin rats1
Empagliflozin + exercise decreases amyloid-beta plaques in amyloid-beta-induced Alzheimer's rat model.
“it diminished necrotic cell death and reduced Aβ plaques”
Animalsin amyloid-beta-induced Alzheimer's rat modelbrain28 days
Current medicinal chemistry
ADP/ATP ratio
upin rats1
1 study
ADP/ATP ratio
upin rats1
Empagliflozin + exercise increases ADP/ATP ratio in amyloid-beta-induced Alzheimer's rat model.
“including target-finding time, traveled distance, time spent in the target quadrant, and ADP/ATP ratios in brain mitochondria”
Animalsin amyloid-beta-induced Alzheimer's rat modelbrain mitochondria28 days
Current medicinal chemistry
Cognitive function
upin rats1
1 study
Cognitive function
upin rats1
Empagliflozin + exercise improves cognitive function in amyloid-beta-induced Alzheimer's rat model.
“the combined program of physical training and empagliflozin treatment in the Aβ-induced AD model drastically improved cognitive functions and neurological parameters”
Animalsin amyloid-beta-induced Alzheimer's rat model28 days
Current medicinal chemistry