Cellular senescence
downin mice1
Elesclomol decreases cellular senescence in mice.
“elesclomol normalized copper-handling programs, improved mitochondrial function, and suppressed ferroptotic stress, hepatocyte senescence, and fibroinflammatory remodeling.”
AnimalsMASLDhepatocyte
bioRxiv : the preprint server for biology17 Jun 2026Preprint
Ferroptotic stress
downin mice1
Elesclomol decreases ferroptotic stress in mice.
“elesclomol normalized copper-handling programs, improved mitochondrial function, and suppressed ferroptotic stress, hepatocyte senescence, and fibroinflammatory remodeling.”
AnimalsMASLDliver
bioRxiv : the preprint server for biology17 Jun 2026Preprint
Mitochondrial function
upin mice1
Elesclomol improves mitochondrial function in mice.
“Targeted restoration of mitochondrial copper with the copper ionophore elesclomol normalized copper-handling programs, improved mitochondrial function”
AnimalsMASLDliver
bioRxiv : the preprint server for biology17 Jun 2026Preprint
Experiments in mice whose ovaries had been removed linked ceruloplasmin deficiency to higher bone mass at the tissue level.Experiments in mice whose ovaries had been removed linked ceruloplasmin deficiency to higher bone mass at the tissue level.