Copper-iron imbalance

Copper-iron imbalance is associated with MASLD progression in humans.

“Across multiple human cohorts and mouse models, copper-iron imbalance tracks with MASLD progression, clinical outcomes, and multiple extrahepatic comorbidities”

HumansMASLD

Disrupted Mitochondrial Copper Homeostasis Promotes Ferroptotic Stress, Senescence and MASLD Progression

bioRxiv : the preprint server for biology·17 Jun 2026Preprint