Dasatinib + quercetin

Papers on dasatinib + quercetin

383 papers9 new in 30 days

Friday, October 30

Aging and DiseaseOct 30

Human colorectal cancer cells become more vulnerable to two drugs

In lab experiments, activating an odor-sensing receptor induced a state resembling senescence, when cells stop dividing, and increased cancer cells’ susceptibility to two…In lab experiments, activating an odor-sensing receptor induced a state resembling senescence, when cells stop dividing, and increased cancer cells’ susceptibility to two drugs.

An enlarged colorectal cancer cell with dark nuclear clusters sits between crowded intact cells and scattered dying cells breaking into fragments.

Human cell studyInterventions

Monday, October 26

ESC Congress 2026 AbstractOct 26

Targeted drug carriers reduced artery calcium buildup in mice

Tiny carriers delivered two cell-clearing drugs in two mouse models, improving survival and avoiding blood-cell side effects associated with dasatinib given without…Tiny carriers delivered two cell-clearing drugs in two mouse models, improving survival and avoiding blood-cell side effects associated with dasatinib given without carriers.

Artery cross-sections show dense calcium deposits beside a clearer wall, with small round drug carriers and a laboratory mouse nearby.

Mouse studyInterventions

ESC Congress 2026 AbstractOct 26

Pharmacological modulation of cardiac senescence reveals divergent transcriptomic reversal patterns in human cardiomyocytes

Experiments in human cellsInterventions

Sunday, October 11

Aging and DiseaseOct 11

Ginkgolide B as a Candidate Gerotherapeutic: Evidence, Evidentiary Limits, and Translational Requirements

ReviewInterventions

Thursday, October 8

Ageing Research ReviewsOct 8

Is there a role for senotherapeutics in the treatment of giant cell arteritis?

ReviewInterventions

Wednesday, October 7

Aging CellOct 7

Exercise or drugs improved heart function in aging mice

A nine-month randomized experiment in 12-month-old mice compared exercise (11 mice), two drugs (15), both (16) and natural aging (12); the interventions improved heart…A nine-month randomized experiment in 12-month-old mice compared exercise (11 mice), two drugs (15), both (16) and natural aging (12); the interventions improved heart performance.

Mice given aerobic exercise, senolytics, or both combined for 9‐months display superior myocardial function to naturally aged mice.

Experiments in miceAerobic exercise

Tuesday, October 6

British Journal of Clinical PharmacologyOct 6

Therapeutic reversal of cellular senescence: A systematic review of senolytics, senomorphics and anti-ageing therapies in human clinical trials

Systematic review of studies in peopleSenolytics

Friday, October 2

Nature MetabolismOct 2

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.

Randomized trial in 31 peopleDasatinib + quercetin

Thursday, October 1

International Journal of Veterinary Sciences and Animal HusbandryOct 1

Senotherapeutics: emerging pharmacological strategies for targeting cellular senescence

ReviewInterventions

Thursday, September 24

Clinical Interventions in AgingSep 24

Therapeutic Targeting of Inflammaging and Emerging Strategies for Managing Age-Related Multimorbidity: A Narrative Review

Cellular senescence and the senescence-associated secretory phenotype (SASP) drive local and systemic inflammaging.

ReviewMultimorbidity

Saturday, September 19

Frontiers in ImmunologySep 19

Chronic low-grade inflammation drives skeletal aging and neurocognitive decline: inflammaging as a central hub coupling bone-brain aging

The integrative landscape of inflammaging, from upstream triggers to systemic pathological outputs.

ReviewInflammation

Friday, September 18

Neurobiology of DiseaseSep 18

Cellular senescence is an early feature and therapeutic target in amyotrophic lateral sclerosis TDP-43Q331K mice

Experiments in miceAmyotrophic lateral sclerosis

Wednesday, September 16

Progress in NeurobiologySep 16

The dimorphic brain in ischemic stroke: How sex and age shape molecular pathophysiology and therapeutic responsiveness

ReviewInflammation

Tuesday, September 15

International ImmunopharmacologySep 15

Radiation-induced atrial fibrillation is driven by cellular senescence via the GATA4 - NF-κB pathway and rescued by D/Q senolytic therapy

Experiments in miceSenolytics

Tuesday, September 8

Frontiers in EndocrinologySep 8

Senescent immune cells, inflammaging, and bone loss: therapeutic potential and translational challenges of senolytics in osteoporosis

Proposed model of the interplay between immune cells with senescence-associated features, inflammaging, and bone remodeling imbalance in osteoporosis.

ReviewSenolytics

Monday, September 7

Journal of Integrative and Translational BiomedicineSep 7

Analysis of Senolytics Sophoretin and Dasatinib across Alzheimer's disease and Annulus Fibrosus Degeneration

Experiments in cellsAlzheimer's disease

Thursday, September 3

Aging and DiseaseSep 3

Senolytic Treatment Triggered by Carotid Occlusion Confers Protection Against Later Acute Ischemic Stroke in Aged Rats

Experiments in ratsSenolytics

GeroScienceSep 3

Targeting cellular senescence mitigates chemotherapy-induced bone loss in young and aged mice

Experiments in miceBones and joints

Tuesday, September 1

NeurotoxicologySep 1

T-2 toxin disrupts Alzheimer's-relevant App/Tau homeostasis via circadian-p53-senescence crosstalk: Evidence from human neuroblastoma cells

Experiments in human cellsProteostasis

Monday, August 31

Drug Design, Development and TherapyAug 31

A Staged Translational Framework for Evaluating Oral Glutamatergic and Senescence-Modulating Strategies in Treatment-Resistant Depression

Candidate glutamatergic and senescence-modulating framework.

CommentaryInterventions

Saturday, August 29

Frontiers in PharmacologyAug 29

Simultaneous induction of differentiation and senescence in cardiac fibroblasts by TGF-β1: effects of senotherapeutics drugs

TGF-β1 induces the differentiation of cardiac fibroblasts (CF) into cardiac myofibroblasts (CMF).

Experiments in rat cellsInterventions

Saturday, August 22

Frontiers in OncologyAug 22

Tumor immunosenescence drives breast cancer progression and therapeutic resistance: mechanisms and emerging interventions

Hallmarks and pathways of tumor cell senescence in breast cancer.

ReviewMechanisms

Wednesday, August 19

Journal of RespirationAug 19

The Role of Cellular Senescence in Chronic Lung Diseases: Emerging Mechanisms and Translational Perspectives: A Narrative Review

ReviewCellular senescence

Thursday, August 13

Cardiovascular ToxicologyAug 13

Senolytics Reverse PM2.5 - Induced Cell and Vascular Dysfunction

Experiments in miceSenolytics

Saturday, August 8

Journal of Bone and Mineral ResearchAug 8

Suppression of early pro-inflammatory senescent signature post-radiotherapy mitigates chronic bone damage

Experiments in miceBones and joints

Thursday, August 6

Authorea PreprintsAug 6

DASATINIB AND QUERCETIN REDUCE ALCOHOL-INDUCED VENTRICULAR LIPID ACCUMULATION, ALCOHOL INTAKE, AND COMPULSIVE-LIKE DRINKING

Preprint: experiments in miceDasatinib + quercetin

Saturday, August 1

Integrative Biomedical ResearchAug 1

Cellular Senescence as a Pathogenic Hub Driving Mechanistic Networks and Reversal Strategies in Idiopathic Pulmonary Fibrosis

Systematic reviewCellular senescence

Friday, July 24

Biochimica et Biophysica Acta Molecular Basis of DiseaseJul 24

Exercise attenuates atherosclerosis by inhibiting eWAT aging via targeting SIRT1/pyruvate carboxylase pathway

Experiments in miceExercise

Wednesday, July 22

Science Translational MedicineJul 22

Drugs improve blood-forming cell function in sickle cell mice

Experiments starting in two-month-old mice found that drugs targeting senescence improved bone marrow cells’ ability to produce blood cells after transplantation.Experiments starting in two-month-old mice found that drugs targeting senescence improved bone marrow cells’ ability to produce blood cells after transplantation.

Study in peopleSickle cell disease

Tuesday, July 14

Journal of Controlled ReleaseJul 14

Enhancing insulin sensitivity by reducing adipocyte senescence using uPAR-targeted nanoparticles in high-fat-diet-induced obese mice

Experiments in miceInterventions