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Celecoxib

InterventionApproved 1998

1 paper

PubChem 2662ChEBI 41423

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 on aging of 380 trials, 192 with no results posted
  • 71 of 380 trials sponsored by its developers

Trials

1 on aging of 380

On aging

Approved

  • FDA Celebrex

    31 Dec 1998Acute Pain, Arthritis, Rheumatoid, Osteoarthritis, Spondylitis, Ankylosing, Arthritis, Juvenile Rheumatoid

  • FDA Celebrex

    23 Dec 1999

  • EMA Onsenal

    17 Oct 2003WithdrawnAdenomatous Polyposis Coli, Polyps, Cancer, Familial Adenomatous Polyposis

  • FDA Elyxyb

    5 May 2020ELYXYB is indicated for the acute treatment of migraine with or without aura in adults. Limitations of Use ELYXYB is not indicated for the…

  • FDA Vyscoxa

    29 Jul 2025Arthritis, Rheumatoid, Osteoarthritis, Spondylitis, Ankylosing, Arthritis, Juvenile Rheumatoid

Repurposing

40 of 107

Every condition in trials

  • Neuroinflammatory Diseases

    Phase 4Completed3 trials

  • Arthroscopy

    Phase 4Completed2 trials

  • Peptic ulcer

    Phase 4Completed2 trials

  • Rotator Cuff Injuries

    Phase 4Completed2 trials

  • Chronic low back pain with a neuropathic component

    Phase 4Terminated1 trial

  • Coronary disease

    Phase 4Completed1 trial

40 of 59

  • Shoulder pain

    Phase 4Active, not recruiting1 trial

  • Lung Neoplasms

    Phase 3Terminated22 trials

  • Breast neoplasm

    Phase 3Results posted21 trials

  • Head and Neck Neoplasms

    Phase 3Terminated15 trials

  • Liver Neoplasms

    Phase 3Completed4 trials

  • Adenocarcinoma of lung

    Phase 3Terminated2 trials

  • Drug-Related Side Effects and Adverse Reactions

    Phase 3Terminated2 trials

  • Migraine Disorders

    Phase 3Results posted2 trials

  • Gouty arthritis

    Phase 3Results posted1 trial

  • Human influenza

    Phase 3Completed1 trial

  • Pharyngitis

    Phase 3Results posted1 trial

  • Prostatic Neoplasms

    Phase 2/3Completed8 trials

  • Mouth Neoplasms

    Phase 2/3Terminated7 trials

  • Narcotic Use

    Phase 2/3Recruiting2 trials

  • Urinary Bladder Neoplasms

    Phase 2/3Completed2 trials

  • Neuroblastoma

    Phase 2Results posted5 trials

  • Central Nervous System Neoplasms

    Phase 2Results posted4 trials

  • Hypopharyngeal Neoplasms

    Phase 2Completed4 trials

  • Laryngeal Neoplasms

    Phase 2Completed4 trials

  • Oropharyngeal Neoplasms

    Phase 2Completed4 trials

  • Recurrence

    Phase 2Recruiting4 trials

  • Squamous Cell Carcinoma of Head and Neck

    Phase 2Completed4 trials

  • Triple Negative Breast Neoplasms

    Phase 2Recruiting4 trials

  • Carcinoma

    Phase 2Recruiting3 trials

  • Gliosarcoma

    Phase 2Results posted3 trials

  • Medulloblastoma

    Phase 2Active, not recruiting3 trials

  • Ovarian neoplasm

    Phase 2Completed3 trials

  • Uterine Cervical Neoplasms

    Phase 2Results posted3 trials

  • Adenocarcinoma Of Esophagus

    Phase 2Completed2 trials

  • Breast Carcinoma In Situ

    Phase 2Terminated2 trials

  • Ependymoma

    Phase 2Active, not recruiting2 trials

  • Locally Advanced Rectal Cancer

    Phase 2Completed2 trials

  • Nasopharyngeal Neoplasms

    Phase 2Completed2 trials

  • No Evidence of Disease

    Phase 2Completed2 trials

Readouts due

Stopped

  • NCT00359151TerminatedOsteoarthritis

    This study was terminated early due to slow enrollment.

  • NCT00585312TerminatedAdenomatous polyposis coli

    See termination reason in detailed description.

  • NCT02987920TerminatedPostoperative pain

    The surgeon changed pain control protocol for all patients. Continued enrollment impossible under approved protocol.

  • NCT00894790TerminatedPain

    See termination reason in detailed description.

  • NCT01838044TerminatedChronic low back pain with a neuropathic component

    Recruitment terminated on 3Apr2015 due to slow recruitment rate and lack of operational feasibility. Study was not terminated for reasons of safety/efficacy.

  • NCT01041781TerminatedNon small cell lung carcinoma

    DSMB recommendation

All 28

  • NCT00305643TerminatedBreast neoplasm

    Terminated due to low accrual. No data analyzed.

  • NCT04176419TerminatedHead and Neck Neoplasms

    Workforce shortage

  • NCT02726659TerminatedPostpartum depression

    Difficulty recruiting participants because principal investigator noticed that the participants in the population were responding well to low doses of mood stabilizers and therefor would not be recruited into the study.

  • NCT00080782TerminatedNeoplasm metastasis

    Low accrual due to competing trial.

  • NCT01067989TerminatedNeoplasm metastasis

    No satisfactory acrual

  • NCT00183807TerminatedEsophageal neoplasms

    Insufficient Accrual

  • NCT00250835TerminatedNeoplasm

    Low accrual

  • NCT04093323TerminatedMelanoma

    Funding completed

  • NCT04162873TerminatedHypopharyngeal Neoplasms

    Insufficient funding

  • NCT01175772TerminatedCarcinoma

    Due to change in the national policy of medications

  • NCT05077969TerminatedCOVID-19

    Low recruitment

  • NCT00088972TerminatedBreast Carcinoma In Situ

    Study closed due to poor accrual.

  • NCT04786548SuspendedObsessive-compulsive disorder

    The NYSPI site is currently paused and has been paused since an institutional pause on human subjects research on March 14, 2024.

  • NCT04115098TerminatedAxial spondyloarthritis

    lack of recruitment

  • NCT01668680TerminatedColorectal cancer metastatic

    No satisfactory acrual

  • NCT05062083TerminatedMultiple sclerosis

    due to futility

  • NCT00256321TerminatedStomach neoplasm

    Closed due to poor accrual

  • NCT01705106TerminatedProtocol specific unspecified adult solid tumor

    The study was terminated early due to slow accrual.

  • NCT01143545TerminatedMalignant mesothelioma

    Closed accrual due to unpromising results and the opening of study 14C0053 targeting the same population.

  • NCT03878524TerminatedMyeloproliferative disorder

    Low accrual

  • NCT02131012TerminatedMacular edema

    Difficulty recruiting

  • NCT03912428TerminatedMyositis

    due to difficulty with participant recruitment and data futility

Trial sponsors

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