Nonsteroidal anti-inflammatory drugs
Nonsteroidal anti-inflammatory drugs has been studied in 17 papers since 2017: 1 trial and 14 observational studies in people, 1 in animals, 1 review; 1 in the past year. The newest paper, Jan 15, 2026: “Baseline morbidity and chronic medications as determinants of sepsis outcomes: focus on statins, corticosteroids, and NSAIDs in a population-based cohort of 59,578 patients”.
17 papers study it12 findingsUpdated
“The significant reduction in the risk of fracture in those allocated to zoledronate (p < 0.0001) showed no interaction with baseline use of NSAIDs (p = 0.33) nor with NSAID use at any time during the study (p = 0.28).”
None of its findings points the other way.
- 10 independent labs in 8 countries
- Funders: National Health Insurance Service and others
- Human trial1
- Humans14
- Animals1
Studies in people
1 study gave nonsteroidal anti-inflammatory drugs to people and measured what changed.
no change: Has no effect on zoledronate efficacy
Randomized trial2,000 peopleWomen6-year
Older adults; Postmenopausal women; Patient cohorts
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Jul 21, 2023
What did studies of Nonsteroidal anti-inflammatory drugs find?
6Studies of Nonsteroidal anti-inflammatory drugs measured 6 outcomes; the most studied are end-stage renal disease (1 study), estimated glomerular filtration rate (1) and activities of daily living (1).
End-stage renal disease
no changein humans1
1 study
End-stage renal disease
no changein humans1
Nonsteroidal anti-inflammatory drugs have no effect on end-stage renal disease in humans.
“End-stage renal disease (ESRD) incidence was rare and not significant.”
Humansn = 1,812
Drugs & aging
Estimated glomerular filtration rate
downin humans1
1 study
Estimated glomerular filtration rate
downin humans1
Nonsteroidal anti-inflammatory drugs decrease estimated glomerular filtration rate in humans.
“NSAID use was associated with an increased CKD risk (HR 1.46; 95% confidence interval (CI) 1.11-1.93) and faster eGFR decline.”
Humansn = 1,812
Drugs & aging
Activities of daily living
upin humans1
1 study
Activities of daily living
upin humans1
Nonsteroidal anti-inflammatory drugs improve activities of daily living in humans (β=2.311, P=0.013).
“Multiple linear regression analysis revealed that NSAIDs use was independently associated with FIM-total gain during hospitalization (β=2.311, P=0.013).”
Humansconvalescent rehabilitation following a fracturen = 261
Journal of pharmaceutical health care and sciences
Anti-SARS-CoV-2 spike RBD IgG
downin humans1
1 study
Anti-SARS-CoV-2 spike RBD IgG
downin humans1
Nonsteroidal anti-inflammatory drugs decrease anti-SARS-CoV-2 spike RBD IgG in humans (aOR = 0.16, 95 %CI; 0.03-0.88).
“regular nonsteroidal anti-inflammatory drugs [NSAIDs] usage (aOR = 0.16, 95 %CI; 0.03-0.88)”
Humansmultivariate analysis after second doseserum
Antibody responses after BNT162b2 vaccination in Japanese geriatric intermediate care facilities
Vaccine: X
Zoledronate efficacy
no changein humans1
1 study
Zoledronate efficacy
no changein humans1
Nonsteroidal anti-inflammatory drugs have no effect on zoledronate efficacy in humans.
“The significant reduction in the risk of fracture in those allocated to zoledronate (p < 0.0001) showed no interaction with baseline use of NSAIDs (p = 0.33) nor with NSAID use at any time during the study (p = 0.28).”
Human trial6-yearfemalesn = 2,000
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Melanoma dissemination
downin zebrafish1
1 study
Melanoma dissemination
downin zebrafish1
Nonsteroidal anti-inflammatory drugs decrease melanoma dissemination in zebrafish.
“we treated melanoma transplants with nonsteroid anti-inflammatory drugs and show that higher melanoma dissemination can be averted”
Animalsmelanoma transplants in G2 tert zebrafish embryos
Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish
Proceedings of the National Academy of Sciences of the United States of America
What is Nonsteroidal anti-inflammatory drugs linked with?
6Studies link Nonsteroidal anti-inflammatory drugs with 6 measures, most often in-hospital mortality (1 study), chronic kidney disease (1) and sarcopenia (1).
In-hospital mortality
upin humans1OR 1.415
1 study
In-hospital mortality
upin humans1OR 1.415
Nonsteroidal anti-inflammatory drugs raise the risk of in-hospital mortality in humans (OR 1.415, 95% CI: 1.226-1.632).
“NSAID use (OR 1.415, 95% CI 1.226-1.632) were linked to increased mortality”
Humansin hospitalised sepsis patients8 months prior to admissionn = 59,578
Frontiers in pharmacology
Chronic kidney disease
upin humans1HR 1.46
1 study
Chronic kidney disease
upin humans1HR 1.46
Nonsteroidal anti-inflammatory drugs raise the risk of chronic kidney disease in humans (HR 1.46, 95% CI 1.11-1.93).
“NSAID use was associated with an increased CKD risk (HR 1.46; 95% confidence interval (CI) 1.11-1.93)”
Humansn = 1,812
Drugs & aging
Sarcopenia
upin humans1
1 study
Sarcopenia
upin humans1
Nonsteroidal anti-inflammatory drugs are associated with sarcopenia in humans (P < 0.05).
“use of nonsteroidal anti-inflammatory drugs (NSAIDs), biologic disease-modifying antirheumatic drugs (bDMARDs), and corticosteroids were significantly (P < 0.05) associated with sarcopenia.”
Humansin Japanese patients with RAn = 2,416
Clinical rheumatology
Impaired driving performance
upin humans1
1 study
Impaired driving performance
upin humans1
Nonsteroidal anti-inflammatory drugs raise the risk of impaired driving performance in humans (aHR 2.72, 95% CI 1.31-5.63).
“nonsteroidal anti-inflammatory drugs (aHR, 2.72; 95% CI, 1.31-5.63) was associated with an increase in risk of receiving a marginal/fail rating on the road test”
Humansn = 198
Medication and Road Test Performance Among Cognitively Healthy Older Adults
JAMA network open
Exudative age-related macular degeneration
downin humans1OR 0.69
1 study
Exudative age-related macular degeneration
downin humans1OR 0.69
Nonsteroidal anti-inflammatory drugs lower the risk of exudative age-related macular degeneration in humans (adjusted OR: 0.69).
“and nonsteroidal anti-inflammatory drug usage (adjusted OR: 0.69).”
Humans
Retina (Philadelphia, Pa.)
Air pollution-associated cognitive impairment
downin humans1
1 study
Air pollution-associated cognitive impairment
downin humans1
Nonsteroidal anti-inflammatory drugs are associated with air pollution-associated cognitive impairment in humans.
“Such adverse effects were attenuated among NSAIDs users compared to non-users.”
HumansPM2.5 exposure; users compared with non-usersmales
Nature aging