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Hesperidin + alternate day fasting

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

4

Neurodegeneration

downin rats1

1 study

  1. Hesperidin + alternate day fasting decreases neurodegeneration in rats.

    “the histopathological changes show well protected neurons and lesser neurodegeneration.”

    Animalsbrainmalesn = 6

    Hesperidin Supplementation During Alternate Day Fasting Provides Synergistic Effect in Conferring Neuroprotection to Aging Rats

    Indian journal of clinical biochemistry : IJCB4 Apr 2024

Oxidative phosphorylation

upin rats1

1 study

  1. Hesperidin + alternate day fasting increases oxidative phosphorylation in rats.

    “The activity of the mitochondrial electron transport chain complexes showed increased efficiency”

    Animalsbrainmalesn = 6

    Hesperidin Supplementation During Alternate Day Fasting Provides Synergistic Effect in Conferring Neuroprotection to Aging Rats

    Indian journal of clinical biochemistry : IJCB4 Apr 2024

More on Oxidative phosphorylation

Oxidative stress and ROS signalling

downin rats1

1 study

  1. Hesperidin + alternate day fasting decreases oxidative stress and ROS signalling in rats.

    “alongwith decrease in MDA, PCO, AOPP, NO and inflammation markers.”

    Animalsbrainmalesn = 6

    Hesperidin Supplementation During Alternate Day Fasting Provides Synergistic Effect in Conferring Neuroprotection to Aging Rats

    Indian journal of clinical biochemistry : IJCB4 Apr 2024

More on Oxidative stress and ROS signalling

Antioxidant defense

upin rats1

1 study

  1. Hesperidin + alternate day fasting increases antioxidant defense in rats.

    “The results provide evidence of a synergistic benefit obtained in crucial parameters of antioxidant defense including FRAP, GSH, SOD, catalase and autophagy expression (Beclin gene)”

    Animalsbrainmalesn = 6

    Hesperidin Supplementation During Alternate Day Fasting Provides Synergistic Effect in Conferring Neuroprotection to Aging Rats

    Indian journal of clinical biochemistry : IJCB4 Apr 2024

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