Alpha-tocopherol
- 2 independent labs in 2 countries
- Funders: Biotechnology and Biological Sciences Research Council and 3 more
- Humans1
- Animals6
Outcomes
4Lifespan
upin mice1
1 study
Lifespan
upin mice1
Alpha-tocopherol extends lifespan in mice (p = 0.028 (oldest 10%)).
“and also increased maximum life span (oldest 10%, p = 0.028).”
Animalscold exposure (7 +/- 2 degrees C)
Rejuvenation research1 Feb 2008
Alpha-tocopherol extends lifespan in mice (+15% (785 days vs 682 days, p = 0.042)).
“Supplementation significantly increased (p = 0.042) median life span by 15% (785 days, n = 44) relative to unsupplemented controls (682 days, n = 43)”
Animalscold exposure (7 +/- 2 degrees C)n = 44
Rejuvenation research1 Feb 2008
Oxidative damage
no changein mice1
1 study
Oxidative damage
no changein mice1
Alpha-tocopherol has no effect on oxidative damage in mice.
“Lymphocyte and hepatocyte oxidative DNA damage and hepatic lipid peroxidation were unaffected by supplementation”
Animalscold exposure (7 +/- 2 degrees C)
Rejuvenation research1 Feb 2008
Metabolic rate
no changein mice1
1 study
Metabolic rate
no changein mice1
Alpha-tocopherol has no effect on metabolic rate in mice.
“treatment having no effect on resting or daily metabolic rate.”
Animalscold exposure (7 +/- 2 degrees C)
Rejuvenation research1 Feb 2008
Thymic lymphoma
no changein mice1
1 study
Thymic lymphoma
no changein mice1
Alpha-tocopherol has no effect on thymic lymphoma in mice.
“continuous administration of alpha-tocopherol did not affect latency to thymic lymphomas.”
Animalsin Atm-deficient mice
Free radical biology & medicine10 May 2006