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Oxidative damage to mtDNA

Biomarker

2 papers2 findings

  • Animals1

Interventions

1

Methionine restriction

downin rats2

2 studies

  1. Methionine restriction decreases oxidative damage to mtDNA in rats.

    “40% MetR (in all the studied organs, heart, brain, liver or kidney) is enough to decrease mtROSp and oxidative damage to mtDNA in rats”

    Review7weeks

    Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction

    Experimental gerontology27 Feb 2013

  2. Methionine restriction decreases oxidative damage to mtDNA in rats.

    “decreases oxidative damage to mtDNA, lowers membrane unsaturation, and decreases all five markers of protein oxidation measured in rat heart and liver mitochondria.”

    Animalsheart and liver mitochondriamales

    Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology1 Jun 2006

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