Senescence-associated secretory phenotype (SASP)
upin mouse cells1
Acetyl-coa increases senescence-associated secretory phenotype (SASP) in mouse cells.
“enhancing acetyl-CoA levels promotes SASP gene expression”
Cellsin senescent cells
Mitochondrial metabolism and epigenetic crosstalk drive SASP
Nature29 Jul 2026
Ovarian aging
upin mice1
Acetyl-coa increases ovarian aging in mice.
“In vivo functional studies demonstrated that acetyl-CoA oversupply accelerated ovarian aging”
Animals
Nature communications15 Jul 2026
Japan Society for the Promotion of ScienceJP¥4.8m
In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.