Abemaciclib

2 papers2 findings

PubChem ChEBI MeSH

1 lab in 1 country

Funder: KWF Kankerbestrijding

Animals2

Outcomes

2

Physical function

upin mice1

1 study

Abemaciclib improves physical function in mice.
“In aged mice, abemaciclib and agn194310 reduced systemic NASP expression and improved physical performance.”
Animals
Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy
Nature aging17 Jul 2026

NF-κB-associated SASP

downin mouse cells1

1 study

Abemaciclib decreases NF-κB-associated SASP in mouse cells.
“short-term inhibition of CDK4/6 with abemaciclib suppresses established NASP in pre-existing senescent cells both in vitro and in vivo.”
Cellspre-existing senescencesenescent cellsshort-term
Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy
Nature aging17 Jul 2026

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