NF-κB-associated SASP

1. AGN194310 decreases NF-κB-associated SASP in mice.

   “In aged mice, abemaciclib and agn194310 reduced systemic NASP expression and improved physical performance.”

   Animals

   Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy

   Nature aging·17 Jul 2026

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1. Abemaciclib decreases NF-κB-associated SASP in mouse cells.

   “short-term inhibition of CDK4/6 with abemaciclib suppresses established NASP in pre-existing senescent cells both in vitro and in vivo.”

   Cellspre-existing senescencesenescent cellsshort-term

   Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy

   Nature aging·17 Jul 2026

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