TXN2

1. TXN2 inhibits FOXO3 nuclear translocation in cells.

   “TRX2 directly bound FOXO3a through a redox-sensitive Cys90-Cys31 disulfide interaction, retaining FOXO3a at the mitochondrial outer membrane and limiting its nuclear translocation.”

   Cellsvascular endothelium

   Protein in blood vessel cells limited bone loss in animals

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·Oct 18, 2026

1. TXN2 has no effect on cell viability in mouse cells.

   “knockdown of Txn2 did not affect cell viability under hydrogen peroxide treatment.”

   Cellsunder hydrogen peroxide treatment

   Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan

   Experimental gerontology·Aug 28, 2020

More on Cell viability

1. TXN2 has no effect on auditory function in mice.

   “Txn2 haplodeficiency did not affect auditory brainstem response threshold, wave I latency, or wave I amplitude at 3-5, 15-16, or 23-25 months of age.”

   AnimalsTxn2 haplodeficiency

   Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan

   Experimental gerontology·Aug 28, 2020

1. TXN2 has no effect on hair cell loss in mice.

   “there were no differences in hair cell loss or spiral ganglion neuron density between WT and Txn2+/- mice at 3-5 or 23-25 months of age.”

   AnimalsTxn2 haplodeficiencyinner ear

   Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan

   Experimental gerontology·Aug 28, 2020

More on Hair cell loss

1. TXN2 has no effect on oxidative stress and ROS signaling in mice.

   “Txn2 haplodeficiency did not affect the thioredoxin or glutathione antioxidant defense in both the mitochondria and cytosol of the inner ears of young mice.”

   AnimalsTxn2 haplodeficiencyinner ear

   Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan

   Experimental gerontology·Aug 28, 2020

More on Oxidative stress and ROS signaling