PRDX5

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab

Animals2
Cells1

Effects

4

Mitochondrial H2O2 production

downin mice1

1 study

PRDX5 decreases mitochondrial H2O2 production in mice.
“These mice also exhibited increased mitochondrial H2O2 production, which upregulated the expression of Atrogin1 and MuRF1 (p < 0.05).”
Animalsskeletal muscle
PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging
Journal of cachexia, sarcopenia and muscle28 Oct 2025

More on Mitochondrial H2O2 production

Muscle regeneration

upin mice1

1 study

PRDX5 improves muscle regeneration in mice.
“Muscle regeneration was impaired in Prdx5-/- mice, with decreased expression of regeneration and mitochondrial transport markers and increased nuclear clustering in regenerating myofibers (p < 0.05).”
Animalsfollowing venom-induced muscle injuryskeletal muscle
PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging
Journal of cachexia, sarcopenia and muscle28 Oct 2025

Treadmill performance

upin mice1

1 study

PRDX5 improves treadmill performance in mice.
“In vivo, 48-week-old Prdx5-/- mice exhibited mitochondrial dysfunction and myonuclear clustering in myofibers, with reduced treadmill performance (p < 0.05).”
Animalsskeletal muscle
PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging
Journal of cachexia, sarcopenia and muscle28 Oct 2025

Myonuclear clustering

downin mouse cells1

1 study

PRDX5 decreases myonuclear clustering in mouse cells (44.4% and 44.9% vs. 17.1% and 21.9%).
“During myogenesis, Prdx5-/- and Prdx3-/-; Prdx5-/- myotubes exhibited impairments in nuclear spreading, characterized by clustered nuclei, unlike the even distribution observed in WT and Prdx3-/- myotubes”
Cellsin myogenesis
PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging
Journal of cachexia, sarcopenia and muscle28 Oct 2025

Latest

2 in 12 months

Cellular and Molecular Life Sciences8 Dec

IER3 drives the transition from sepsis-associated AKI to CKD by suppressing the mitochondrial translocation of PRDX5

Experiments in miceMitochondrion

Bulletin of Experimental Biology and Medicine6 Nov

Modifications of the Secretome of Mesenchymal Stromal Cells under Conditions of Stress-Induced Aging

Experiments in human cellsMechanisms

Journal of Cachexia, Sarcopenia and Muscle28 Oct

PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging

Experiments in miceOxidative phosphorylation