SLC17A5

SLC17A5 is required for dentin bridge formation and tissue repair in mice.

“local nitrate accelerated dentin bridge formation and tissue repair, but these effects were lost in mesenchymal Sialin conditional-knockout mice.”

AnimalsRequired for nitrate benefits in a pulp exposure model, shown by mesenchymal Sialin conditional knockoutdental pulp and dentin

Nitrate-Sialin Promotes Dentin Regeneration via Mitochondrial Rewiring

Journal of dental research·28 May 2026

SLC17A5 is required for antisenescence and odontogenic benefits in mouse cells.

“Silencing Sialin abolished these benefits, establishing pathway necessity.”

CellsRequired for nitrate benefits, shown by Sialin silencingdental pulp stem cells

Nitrate-Sialin Promotes Dentin Regeneration via Mitochondrial Rewiring

Journal of dental research·28 May 2026