PTGFR
- 1 lab in 1 country
- Funders: National Natural Science Foundation of China and 1 more
- Animals2
Effects
7Cardiac remodeling
upin mice1
1 study
Cardiac remodeling
upin mice1
PTGFR increases cardiac remodeling in mice.
“the inhibition of FP receptor could improve aging-related cardiac remodeling”
Animalsaging-relatedheart
Archives of gerontology and geriatrics
PI3K–AKT signaling
upin mice1
1 study
PI3K–AKT signaling
upin mice1
PTGFR activates PI3K–AKT signaling in mice.
“FP receptor could activate PI3K/AKT/mTOR pathway”
Animalsin aging miceheart
Archives of gerontology and geriatrics
Autophagy
downin mice1
1 study
Autophagy
downin mice1
PTGFR inhibits autophagy in mice.
“FP receptor could activate PI3K/AKT/mTOR pathway and inhibit cardiac autophagy”
Animalsin aging miceheart
Archives of gerontology and geriatrics
Cardiac fibrosis
upin mice1
1 study
Cardiac fibrosis
upin mice1
PTGFR increases cardiac fibrosis in mice.
“FP receptor could activate PI3K/AKT/mTOR pathway and inhibit cardiac autophagy, which resulted in aging-related cardiac fibrosis.”
Animalsin aging miceheart
Archives of gerontology and geriatrics
Cellular senescence
upin mouse cells1
1 study
Cellular senescence
upin mouse cells1
PTGFR induces cellular senescence in mouse cells.
“FP receptor could promote VSMC senescence by upregulated Src/PAI-1 signal pathway”
Cellsin vitro
PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway
Oxidative medicine and cellular longevity
Vascular fibrosis
downin mice1
1 study
Vascular fibrosis
downin mice1
PTGFR decreases vascular fibrosis in mice.
“improving the excessive deposition of ECM and delaying the process of vascular fibrosis”
Animalsshown by gene silencing
PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway
Oxidative medicine and cellular longevity
Oxidative stress and ROS signaling
downin mice1
1 study
Oxidative stress and ROS signaling
downin mice1
PTGFR inhibits oxidative stress and ROS signaling in mice.
“FP receptor gene silencing can ameliorate vascular aging and inhibit oxidative stress”
Animalsshown by gene silencing
PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway
Oxidative medicine and cellular longevity