Imp

1. Imp is required for piwi nuclear localization in flies.

   “Moreover, Imp associates with piRNA pathway proteins, ensures Piwi nuclear localization, and—like piwi mutants—its loss disrupts TE silencing and causes position-effect variegation (PEV) defects.”

   Model organismsloss of Imp

   Imp, a key regulator of transposable elements, cell growth, and differentiation genes during embryogenesis

   bioRxiv (Cold Spring Harbor Laboratory)·30 Sep 2025Preprint

1. Imp inhibits Copia in flies.

   “Specifically, the Ty1 family retrotransposon Copia was derepressed.”

   Model organismsin Imp mutants

   Imp, a key regulator of transposable elements, cell growth, and differentiation genes during embryogenesis

   bioRxiv (Cold Spring Harbor Laboratory)·30 Sep 2025Preprint

More on Copia

1. Imp inhibits transposable element activity in flies.

   “Embryos derived from Imp mutant germline clones arrest development, and transcriptome analysis revealed significant dysregulation of genes involved in cell growth, differentiation, tube morphogenesis, neuronal projection development, and RNA metabolism, along with de-repression of transposable element (TE) RNAs.”

   Model organismsImp mutant germline clones

   Imp, a key regulator of transposable elements, cell growth, and differentiation genes during embryogenesis

   bioRxiv (Cold Spring Harbor Laboratory)·30 Sep 2025Preprint

More on Transposable element activity

1. Imp impairs synaptic bouton formation in flies.

   “Reduced levels of Imp at the larval neuromuscular junction (NMJ) impair synaptic bouton formation and decrease adult longevity.”

   Model organismsreduced levels of Implarval neuromuscular junction

   Imp, a key regulator of transposable elements, cell growth, and differentiation genes during embryogenesis

   bioRxiv (Cold Spring Harbor Laboratory)·30 Sep 2025Preprint

1. Imp decreases testis aging in flies.

   “Aging of the testis is reversed by increasing BMPs in the niche, or by overexpressing Imp or depleting Hairless in GSCs.”

   Model organismstestis

   Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo

   bioRxiv : the preprint server for biology·3 May 2025Preprint

1. Imp increases Ilp3 in flies.

   “the expression of two of the insulin-like peptides encoded in the fly genome, dilp2 and dilp3, were found to be downregulated.”

   Model organismsimp mutant

   Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22

   Journal of diabetes research·2 Mar 2015

More on Ilp3

1. Imp increases Ilp2 in flies.

   “the expression of two of the insulin-like peptides encoded in the fly genome, dilp2 and dilp3, were found to be downregulated.”

   Model organismsimp mutant

   Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22

   Journal of diabetes research·2 Mar 2015

More on Ilp2

1. H decreases Imp in flies.

   “Elevated Hairless reduces the RNA binding protein Imp, causing loss of the stem cell factor Chinmo”

   Model organismstestis

   Age-related decline in niche self-renewal factors drives testis aging via Hairless, Imp, and Chinmo

   Science advances·26 Jun 2026

More on H