H

1. H decreases Imp in flies.

   “Elevated Hairless reduces the RNA binding protein Imp, causing loss of the stem cell factor Chinmo”

   Model organismstestis

   Age-related decline in niche self-renewal factors drives testis aging via Hairless, Imp, and Chinmo

   Science advances·26 Jun 2026

More on Imp

1. H increases stem cell competition in flies.

   “GSC clones with reduced Imp or increased Hairless are more competitive, expelling wild-type neighbors and monopolizing the niche.”

   Model organismstestis

   Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo

   bioRxiv : the preprint server for biology·3 May 2025Preprint

1. H increases testis aging in flies.

   “Aging of the testis is reversed by increasing BMPs in the niche, or by overexpressing Imp or depleting Hairless in GSCs.”

   Model organismstestis

   Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo

   bioRxiv : the preprint server for biology·3 May 2025Preprint

1. bone morphogenetic protein signaling decreases H in flies.

   “levels of niche cell-derived bone morphogenetic protein (BMP) signals decline with age, leading to increased expression of the transcriptional corepressor Hairless in germline stem cells (GSCs).”

   Model organismstestis

   Age-related decline in niche self-renewal factors drives testis aging via Hairless, Imp, and Chinmo

   Science advances·26 Jun 2026