What does the research say about IL1B?

IL1B

There are 13 papers on IL1B in aging research: 1 trial in people, 5 in animals, 2 in cells, 4 reviews. The newest story, Nov 3, 2026: “Blood-cell gene loss impairs heart recovery in mice”.

Gene

13 papers study it2 findings

HGNC NCBI Gene Taxon

2 new papers in 30 daysSee all 13

None of its findings points the other way.

2 independent labs in 2 countries
40 trials, 5 with no results posted

39 of 40 trials sponsored by developers of drugs aimed at it

Human trial1
Animals5
Cells2
In silico1

Interventions

Advanced age

upin E. caballus1

1 study

Advanced age increases IL1B in E. caballus after LPS stimulation.
“In the senior group, the expression of IL-1β in 2 h-0.01 μg/mL LPS-stimulated PBMCs was significantly higher than in the young adult group”
Animalsafter LPS stimulationperipheral blood mononuclear cells0.01 μg/mL LPS2 hn = 7
Effect of aging on monocyte phagocytic and inflammatory functions, and on the ex vivo inflammatory responses to lipopolysaccharide, in horses
Veterinary immunology and immunopathologyJul 12, 2022

Upstream

PHLDA1

upin human cells1

1 study

PHLDA1 increases IL1B in human cells.
“PHLDA1 promotes IL-1β expression”
Cells
PHLDA1 is a shared diagnostic and key mediator of inflammatory fibrosis in heart and kidney
Frontiers in immunologyFeb 5, 2026

Latest

12 papers in 12 months

Nature Cardiovascular ResearchNov 3

Blood-cell gene loss impairs heart recovery in mice

In mouse experiments, blocking an immune signal counteracted the harmful heart effects of losing KDM6A in blood-forming cells.In mouse experiments, blocking an immune signal counteracted the harmful heart effects of losing KDM6A in blood-forming cells.

Mouse studyMechanisms