GHRH

1. GHRH decreases body weight in rats (half the body weight).

   “Physiological characterization of GHRH knockout (KO) rats revealed that they were half the body weight of wild-type controls.”

   Animalsknockout

   A Novel GH Deficient Rat Model Reveals Cross-Species Insights Into Aging

   Aging cell·5 Jun 2025

1. GHRH decreases ceramide in mice.

   “GHRH-KO mice showed pronounced downregulation of numerous ceramides and hexosylceramides”

   AnimalsGHRH-KOliverfemales

   Unveiling ceramide dynamics: Shedding light on healthy aging in growth hormone-releasing hormone knockout mice

   Aging cell·29 May 2024

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1. GHRH decreases pancreatic beta cells in mice.

   “alterations in pancreatic islet architecture, with smaller islets and a reduction of insulin-producing beta cells”

   AnimalsGHRH knockoutpancreasfemales

   Distinct physiological characteristics and altered glucagon signaling in GHRH knockout mice: Implications for longevity

   Aging cell·4 Sep 2023

More on Pancreatic beta cells

1. GHRH decreases GCGR in mice.

   “analysis of hepatic glucagon signaling showed a decrease in glucagon receptor expression and phosphorylated CREB”

   AnimalsGHRH knockoutliverfemales

   Distinct physiological characteristics and altered glucagon signaling in GHRH knockout mice: Implications for longevity

   Aging cell·4 Sep 2023

More on GCGR

1. CNR1 increases GHRH in mice.

   “Cnr1-/- mice had reduced hypothalamic expression of GHRH and lower IGF-1 plasma levels”

   AnimalsCnr1-/- micehypothalamus

   Shorter life- and health-span, disturbed insulin-like growth factor signalling in cannabinoid receptor type-1 knockout mice

   Experimental gerontology·17 Jun 2025

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1. GHRH is associated with microbiome composition in rats.

   “Analysis of the gut microbial community in adult GHRH-KO rats further revealed a less diverse male microbiome, but a more diverse female KO microbiome compared to controls.”

   Animalsknockout

   A Novel GH Deficient Rat Model Reveals Cross-Species Insights Into Aging

   Aging cell·5 Jun 2025

More on Microbiome composition

1. GHRH is associated with mitochondrial metabolites in mice.

   “mitochondrial metabolites are differentially regulated in GHRH-KO”

   Animalsin blood serum

   Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism

   Aging·23 Feb 2020