There are 10 papers on DNMT in aging research: none in people yet, 6 in animals, 3 in cells, 1 review.
At a glance
The findings reach mice, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: American Heart Association and 2 more
- Animals5
- Model organisms1
- Cells3
Effects
1CDKN1A
mediatesin human cells1
1 study
CDKN1A
mediatesin human cells1
DNMT mediates CDKN1A in human cells (shown by DNMT inhibition with 5-aza-dC or zebularine in OCT4-expressing cells).
“The inhibition of DNMTs reversed the OCT4-induced p21 reduction, depleted the self-renewal of hHFMSCsOCT4, and triggered cell senescence.”
Cellsshown by DNMT inhibition with 5-aza-dC or zebularine in OCT4-expressing cells
Stem cell research & therapy
Associations
1DNA methylation of SOD1, SOD2, SIRT1 and NOX4
upin mice1
1 study
DNA methylation of SOD1, SOD2, SIRT1 and NOX4
upin mice1
DNMT is associated with DNA methylation of SOD1, SOD2, SIRT1 and NOX4 in mice (Ang-II-treated aged mice).
“the expressions of DNMTs were increased and associated with increased methylation of SODs, Sirt1, and Nox4”
AnimalsAng-II-treated aged micekidney1000 ng/kg/min4 weeks
Methylation-dependent antioxidant-redox imbalance regulates hypertensive kidney injury in aging
Redox biology