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RG108

Intervention

3 papers study it5 more mention it6 findings

PubChemMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 3 independent labs in 3 countries
  • Funders: Fondazione CRT and 3 more
  • Humans2
  • Model organisms1

Outcomes

6

SIRT1

upin B. terrestris1

1 study

  1. RG108 increases SIRT1 in B. terrestris.

    “the longevity gene sirt1 was overexpressed following the treatment.”

    Model organismsfollowing RG108 treatment

    DNA methylation extends lifespan in the bumblebee Bombus terrestris

    Proceedings. Biological sciencesDec 6, 2023

More on SIRT1

Lifespan

upin B. terrestris1+43% mean lifespan

1 study

  1. RG108 extends lifespan in B. terrestris (+43% mean lifespan).

    “RG108 extended mean lifespan by 43%”

    Model organisms

    DNA methylation extends lifespan in the bumblebee Bombus terrestris

    Proceedings. Biological sciencesDec 6, 2023

Apoptosis

no changein human cells1

1 study

  1. RG108 has no effect on apoptosis in human cells.

    “RG108 did not affect the proliferation and apoptosis of PDLSCs”

    Cellsin periodontal ligament stem cellsperiodontal ligament stem cells

    Senescent Markers Expressed by Periodontal Ligament-Derived Stem Cells (PDLSCs) Harvested from Patients with Periodontitis Can Be Rejuvenated by RG108

    BiomedicinesSep 14, 2023

More on Apoptosis

Stem cell differentiation

upin human cells1

1 study

  1. RG108 increases stem cell differentiation in human cells.

    “adipogenic potential increased in pPDLSCs after treatment”

    Cellsin periodontitis-derived periodontal ligament stem cellsperiodontal ligament stem cells100 μM

    Senescent Markers Expressed by Periodontal Ligament-Derived Stem Cells (PDLSCs) Harvested from Patients with Periodontitis Can Be Rejuvenated by RG108

    BiomedicinesSep 14, 2023

More on Stem cell differentiation

Cellular senescence

downin human cells1

1 study

  1. RG108 decreases cellular senescence in human cells.

    “a significant reduction of both p16 and p21 was detected along with an increase of SOX2 and OCT4 in pPDLSCs after treatment at 100 μM RG108”

    Cellsin periodontitis-derived periodontal ligament stem cellsperiodontal ligament stem cells100 μM

    Senescent Markers Expressed by Periodontal Ligament-Derived Stem Cells (PDLSCs) Harvested from Patients with Periodontitis Can Be Rejuvenated by RG108

    BiomedicinesSep 14, 2023

More on Cellular senescence

Spatial memory

downin Vertebrata1

1 study

  1. RG108 impairs spatial memory in Vertebrata.

    “Hippocampal DNMT inhibition in young animals was sufficient to recapitulate the behavioral deficits observed in aged animals and abolished the memory-enhancing and molecular effects of PrL DBS.”

    Animalsin young animalshippocampus

    Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms

    Aging and diseaseFeb 1, 2023

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