Tet

Tet prevents stem cell exhaustion in flies.

“adult-specific loss drives progressive stem cell exhaustion”

Model organismsadult-specific lossgut

Intrinsic regulation of intestinal stem cell fate and homeostasis by Tet

bioRxiv : the preprint server for biology·8 May 2026Preprint

Tet prevents premature muscle aging in flies.

“analysis of TET-catalytic inactive flies also highlights the enzyme's critical role in adult fly mobility and its ability to prevent premature muscle aging.”

Model organismsvia catalytic activityflight muscle

TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging

Skeletal muscle·27 Oct 2025

Tet improves mobility in flies.

“analysis of TET-catalytic inactive flies also highlights the enzyme's critical role in adult fly mobility”

Model organismsvia catalytic activity

TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging

Skeletal muscle·27 Oct 2025

Tet decreases flight muscle organization disruption in flies.

“Tet loss leads to a decrease in the number of adult muscle progenitors in the larva, dysregulation of the myogenic expression program in the pupa and disrupted flight muscle organization in the adult.”

Model organismsin Drosophila melanogasterindirect flight muscle

TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging

Skeletal muscle·27 Oct 2025