KLHL22

2 papers3 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Cells1
In silico1

Effects

3

Breast cancer

downin mice1

1 study

KLHL22 decreases breast cancer in mice.
“Depletion of KLHL22 in breast cancer cells suppresses tumour growth in nude mice.”
Animalsin nude micebreast
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing
Nature16 May 2018

More on Breast cancer

mTOR signalling

upin cells1

1 study

KLHL22 activates mTOR signalling in cells.
“KLHL22 plays a conserved role to mediate the activation of mTORC1”
Cellsin response to amino acids
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing
Nature16 May 2018

More on mTOR signalling

DEPDC5

downin cells1

1 study

KLHL22 decreases DEPDC5 in cells.
“the CUL3-KLHL22 E3 ubiquitin ligase promotes K48-linked polyubiquitination and degradation of DEPDC5”
Cellsin response to amino acids
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing
Nature16 May 2018

Latest

bioRxiv19 May

Age-Related KLHL22 Expression in Human MSCs and Regenerative Implications

Preprint: computational studyMechanisms

Nature16 May

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing

Experiments in human cellsmTOR signalling