daf-16

GeneCaenorhabditis elegans4 papers2 findingsNCBI Gene 172981Taxon 6239

Animals1
Model organisms3

Interventions

Perilla frutescens

upin worms1

1 study

Perilla frutescens activate daf-16 in worms.
Model organismsethyl acetate leaf extract
Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway · Biogerontology · 26 Sep 2026

Perilla frutescens →

Effects

Lifespan

is required forin worms1

1 study

daf-16 is required for lifespan in worms.
Model organismsfor EBHM-induced lifespan extension
Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice · Biogerontology · 25 Sep 2026

Latest

Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway

Model organismsBiogerontology28 Sep

Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions

Model organismsFoods (Basel, Switzerland)28 Sep

AnimalsPeer-reviewedNAD+ & sirtuins26 Sep

Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice

The herbal extract activates AMPK-SIRT1 signaling, enhancing antioxidant defenses and modulating apoptosis to alleviate tissue aging across both model organisms.

Biogerontology · Pu Y et al.

Paper

Turnera diffusa polysaccharides promote healthy aging through conserved stress response regulation and metabolic remodeling across multiple aging models

Model organismsBiogerontology26 Sep