Neurodegeneration
Disease1 paper
Latest
24Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
Model organisms
Fruit flies provide an in vivo model to study ferroptosis and lifespan
Ferroptosis-inducing compounds shortened fly lifespan in a diet-dependent manner, while antioxidant treatment restored longevity and reversed iron-related changes in males.
Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies
Young flies housed alone showed faster retrovirus activation and more aggressive protein spread from glia to neurons.