Reproductive dysfunction
1 paper1 finding
Associations
1Cellular senescence
upin humans1
1 study
Cellular senescence
upin humans1
Cellular senescence raises the risk of reproductive dysfunction in humans.
“pathological accumulation of senescent cells drives chronic inflammation, fibrosis, and reproductive dysfunction”
Review
International journal of biological sciences20 Oct 2025
Latest
6 in 12 monthsJournal of Ethnopharmacology
Tokishakuyakusan ameliorates age-related pregnancy loss by modulating endocrine, inflammatory, and placental factors in an advanced maternal age rat model
Experiments in ratsInterventions
Journal of Ovarian Research
NMN/NAD⁺/SIRT1 axis activates NAMPT to ameliorate H₂O₂-triggered the impairment of progesterone synthesis in ovarian granulosa cells
Experiments in mouse cellsNicotinamide mononucleotide
iScience
Reduced Akr1b7 signaling drives ovarian aging and reproductive dysfunction
Experiments in micePI3K–AKT signalling
European Journal of Pharmacology
GLP-1RA partially alleviates obesity-induced reproductive dysfunction driven by the interplay mechanisms of inflammation and metabolic dysregulation via the SIRT-associated pathway
Experiments in animalsInterventions
International Journal of Biological Sciences
Cellular Senescence in Endometrium: A Pivotal Regulator in Physiological Remodeling and Pathological Disorders
Human Reproduction
Rotating night shift work and menopausal age
Cohort study of 80,840 peoplePopulations