NAMPT expression

2 papers2 findings

Animals1
In silico1

Upstream

2

Psychiatric disorder

downin silico1

1 study

Psychiatric disorder decreases NAMPT expression in silico (mean Z of -2.89).
“NAMPT, the rate-limiting enzyme in NAD+ salvage, showed consistent downregulation, with a mean Z of -2.89.”
In silicoacross major depressive disorder, bipolar disorder, obsessive-compulsive disorder, and schizophrenia
Polygenic Constraints on NAD⁺ Metabolism in Major Psychiatric Illness: Mechanistic Support for NMN Supplementation
Figshare30 Mar 2026Preprint

More on Psychiatric disorder

MIR146A

downin cells1

1 study

MIR146A decreases NAMPT expression in cells.
“Mechanistically, miR-146a directly targeted the 3'-UTR of Nampt mRNA to reduce the expression of NAMPT.”
Cells
miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD⁺/SIRT inactivation
Signal transduction and targeted therapy4 Mar 2022

More on MIR146A

Latest

5 in 12 months

Frontiers in Bioscience30 Sep

Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells

Experiments in human cellsCellular senescence

Experimental Gerontology20 Sep

Preliminary findings on the enhancement of skeletal muscle structure and function in aged male mice by P7C3 activation of nicotinamide phosphoribosyl transferase (NAMPT)

Experiments in miceMuscle

Research Square27 Aug

Low-dose lithium prevents age-dependent metabolic stress–driven alzheimer’s disease–like pathology through restoration of the NAMPT–NAD⁺–SIRT1–AMPK–TFEB metabolic resilience network

Preprint: experiments in miceLithium

Frontiers in Medicine12 Aug

NAMPT shows tissue-dependent immune-metabolic associations in osteoarthritic synovium and aging-related skeletal muscle

Computational studyOxidative phosphorylation

Figshare30 Mar

Polygenic Constraints on NAD⁺ Metabolism in Major Psychiatric Illness: Mechanistic Support for NMN Supplementation

Preprint: computational studyNAD+ metabolism

Signal Transduction and Targeted Therapy4 Mar

miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD⁺/SIRT inactivation

Experiments in animalsAMPK signalling

Chinese Journal of Cancer14 Jun

Nampt is involved in DNA double-strand break repair

Experiments in human cellsDNA repair