Radiation-induced pulmonary fibrosis
2 papers2 findings
- Animals2
Interventions
2D-phe-pro-arg-chloromethylketone
downin mice1
1 study
D-phe-pro-arg-chloromethylketone
downin mice1
D-phe-pro-arg-chloromethylketone decreases radiation-induced pulmonary fibrosis in mice.
“Targeting GZMK alleviated fibrosis, highlighting its potential as a therapeutic target for radiation-induced lung injury.”
Animalsradiation-induced lung injurylungfrom week 12 post-irradiation
Archives of biochemistry and biophysics6 Jul 2026
Emodin
downin mice1
1 study
Emodin
downin mice1
Emodin protects against radiation-induced pulmonary fibrosis in mice.
“emodin treatment significantly attenuated pulmonary fibrosis, reduced collagen deposition, and downregulated fibrotic markers.”
Animalsradiation-inducedlung16 Gy thoracic irradiation
Biogerontology6 Jul 2026
Latest
3 in 12 monthsArchives of Biochemistry and Biophysics
Targeting CD8⁺ T cell-derived granzyme K alleviates radiation-induced pulmonary fibrosis by attenuating senescence and SASP
Experiments in miceSenescence-associated secretory phenotype (SASP)
Biogerontology
Emodin alleviates radiation-induced pulmonary fibrosis by targeting cellular senescence via the mtDNA-cGAS-STING axis
Experiments in miceLung
Signal Transduction and Targeted Therapy
Targeting the senescence‒autophagy axis via p16INK4a inhibition alleviates pulmonary fibrosis
Experiments in animalsInterventions
Free Radical Biology & Medicine
NRF2 deficiency reduces life span of mice administered thoracic irradiation
Experiments in animalsMechanisms