GRANZYMEK

1 paper1 finding

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals1

Effects

1

Cellular senescence

upin mouse cells1

1 study

GRANZYMEK induces cellular senescence in mouse cells.
“In vitro, GZMK directly induced cellular senescence and activated the p53/p21/p16 pathway along with SASP factor expression.”
Cellsin MLE12 and MH-S cells treated with recombinant GZMKrecombinant protein
Targeting CD8⁺ T cell-derived granzyme K alleviates radiation-induced pulmonary fibrosis by attenuating senescence and SASP
Archives of biochemistry and biophysics6 Jul 2026

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Targeting CD8⁺ T cell-derived granzyme K alleviates radiation-induced pulmonary fibrosis by attenuating senescence and SASP

Experiments in miceSenescence-associated secretory phenotype (SASP)