D-phe-pro-arg-chloromethylketone

1. D-phe-pro-arg-chloromethylketone decreases cellular senescence in mice.

   “In vivo inhibition of GZMK markedly attenuated lung collagen deposition, myofibroblast activation, senescent cell burden, and levels of SASP factors (IL-6, TNF-α, TGF-β).”

   Animalsin vivo post-irradiationlungfrom week 12 post-irradiation

   Targeting CD8⁺ T cell-derived granzyme K alleviates radiation-induced pulmonary fibrosis by attenuating senescence and SASP

   Archives of biochemistry and biophysics·6 Jul 2026

More on Cellular senescence

1. D-phe-pro-arg-chloromethylketone decreases radiation-induced pulmonary fibrosis in mice.

   “Targeting GZMK alleviated fibrosis, highlighting its potential as a therapeutic target for radiation-induced lung injury.”

   Animalsradiation-induced lung injurylungfrom week 12 post-irradiation

   Targeting CD8⁺ T cell-derived granzyme K alleviates radiation-induced pulmonary fibrosis by attenuating senescence and SASP

   Archives of biochemistry and biophysics·6 Jul 2026

More on Radiation-induced pulmonary fibrosis