Neurodegenerative processes

Disease

1 paper

Model organisms1

Funding

1 grant since 2017

Agencia Nacional de Investigación y DesarrolloCLP 257.8k

AGE-RELATED CHANGES IN THE REGULATION OF NEUROINFLAMMATION RELEVANCE IN NEURODEGENERATIVE PROCESSES
Agencia Nacional de Investigación y DesarrolloPontificia Universidad Catolica de ChileCLP 257.8k2017–2021

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88 in 12 months

medRxivYesterday

One brain region was smaller than expected in neurological disease

An observational study of 81,870 UK Biobank participants aged 45–87 linked lower-than-expected volume in this region to later dementia and Parkinson’s disease.An observational study of 81,870 UK Biobank participants aged 45–87 linked lower-than-expected volume in this region to later dementia and Parkinson’s disease.

Preprint: cohort study of 81,870 UK Biobank participants aged 45–87Mechanisms

Limit: Early neurodegeneration could cause lower volume, rather than lower volume causing disease

Paper

Revista Ibero-Americana de Humanidades, Ciências E EducaçãoYesterday

Neurotoxic mechanisms of alcohol and their relationship with neurodegenerative diseases: a literature review

ReviewMechanisms

Paper

Optometría Clínica y Ciencias de la Visión15 Oct

Retinal Biomarkers of Neurodegeneration: The Emerging Role of Optical Coherence Tomography (OCT) and Artificial Intelligence (IA)

ReviewBiomarkers

Paper

PLOS One14 Oct

Personalized assessment of high-definition slow-oscillatory transcranial direct current stimulation (so-tDCS) in older adults with sleep and subjective cognitive complaints: A study protocol for a randomized clinical trial

Study protocolInterventions

Paper

American Journal of Hypertension8 Oct

Aldosterone, the brain, and the blood pressure ceiling: a neurological case for aldosterone synthase inhibitors in resistant hypertension

ReviewHypertension

Paper

Research Square2 Oct

Count-based records top foundation models for dementia risk

At 36 months before diagnosis, count-based models reached an AUROC of 0.738 compared with 0.719 for pretrained foundation models in All of Us records.At 36 months before diagnosis, count-based models reached an AUROC of 0.738 compared with 0.719 for pretrained foundation models in All of Us records.

Preprint: computational studyAlzheimer's disease and related dementias

Paper

Research Square2 Oct

Compartment-resolved brain aging reveals distinct vascular and neurodegenerative pathways

Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.

Preprint: cohort study of 26,446 peopleBiomarkers

Paper

Glia1 Oct

Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice

The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.

Experiments in miceInterventions

Paper

Cureus30 Sep

Diet, Microbiota and Memory: How What We Eat Affects Memory and Cognitive Processes and Whether Diet Can Help Prevent the Onset of Dementia

ReviewDementia

Paper

bioRxiv26 Sep

Microplastics induce senescence in human brain organoids

Exposures to synthetic and ocean-derived micro- and nanoplastics activated senescence pathways and altered neuronal network activity in region-specific cortical…Exposures to synthetic and ocean-derived micro- and nanoplastics activated senescence pathways and altered neuronal network activity in region-specific cortical organoids.

Preprint: experiments in human cellsCellular senescence

Paper

Neurodegenerative processes

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