Neoplastic transformation

4 papers

Animals1
Cells3

Latest

Cell Death and Differentiation20 Aug

PUMA-induced apoptosis drives bone marrow failure and genomic instability in telomerase-deficient mice

Experiments in miceTelomerase and telomere maintenance

npj Aging3 Aug

Endo180 and basement membrane stiffness induce OXPHOS and neoplastic transformation in aging prostate epithelia

Cohort study in peopleOxidative phosphorylation

Antioxidants29 Jul

Oxidative Stress, Parity History, and Remnant Follicles in the Aged Ovary: Insights on Ovarian Cancer Risk and Protection

ReviewOxidative stress and ROS signalling

PNAS18 Jun

Tumor-promoting UBR4 coordinates impaired mitophagy-associated senescence and lung adenocarcinoma pathogenesis

Experiments in miceMitophagy

bioRxiv3 Feb

Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities

Preprint: experiments in animalsMechanisms

PNAS8 Jan

The cGAS-STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM-deficient murine lung fibroblasts

Experiments in mouse cellsp38 MAPK signalling

Autophagy8 Aug

Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases

ReviewMechanisms

Philosophical Transactions of the Royal Society of London, Series B4 Mar

On epigenetic stochasticity, entropy and cancer risk

ReviewMechanisms

Seminars in Hematology11 Feb

Immune-driven clonal cell selection at the intersection among cancer, infections, autoimmunity and senescence

ReviewImmune response

Mechanisms of Ageing and Development23 Nov

The skin of the naked mole-rat and its resilience against aging and cancer

ReviewMechanisms