Immune dysfunction

Disease

3 papers

  • Humans1
  • Animals2

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Blood-cell telomerase delays premature aging in zebrafish

Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere…Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere length.

Preprint: experiments in zebrafishTelomerase and telomere maintenance
Frontiers in Immunology

Fungus drives spleen aging in mice, eased by astragaloside IV

In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis.

Experiments in miceInterventions